p16 Expression Is Lost in Severely Atypical Cellular Blue Nevi and Melanoma Compared to Conventional, Mildly, and Moderately Atypical Cellular Blue Nevi

p16 Expression Is Lost in Severely Atypical Cellular Blue Nevi and Melanoma Compared to Conventional, Mildly, and Moderately Atypical Cellular Blue Nevi

Background. Significant decreases in p16 expression have been shown to occur in melanoma compared to Spitz tumors, and loss of p16 staining has been found to correlate with melanoma tumor progression. However, comparison of p16 between atypical cellular blue nevi (CBN) and melanoma has not been reported previously. Methods. p16 immunohistochemical staining was evaluated in 14 atypical CBN, 8 co...

Blue Conjunctival Nevi: A Benign Tumor of Atypical Localization, Conjunctival Blue Nevus: Benign Tumor Formed at an Atypical Location

Atypical cellular blue nevus or malignant blue nevus?*

Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progre...

Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update

The clinicopathologic classification, diagnosis, and management of Spitzoid melanocytic lesions is one of the most problematic topics in dermato-oncology and dermatopathology. After earlier anecdotal reports [1,2], the controversial history of these controversial lesions began in 1948 when Sophie Spitz described 13 cases of what she called “juvenile melanoma,” underlining its presumably good pr...

Dermoscopic classification of atypical melanocytic nevi (Clark nevi).

OBJECTIVES To create a dermoscopic classification of atypical melanocytic nevi (Clark nevi) and to investigate whether individuals bear a predominant type. DESIGN Digital dermoscopic images of Clark nevi were classified according to structural features, ie, reticular, globular, or homogeneous patterns or combinations of these types. The nevi were also characterized as central hypopigmented or...